Objective To understand epidemiologic features of Nanning city from 2008 to 2011 and provide reference for the prevention and control of hand foot mouth disease. Method Using descriptive epidemiological method,the data of hospital outpatient and inpatient children with hand foot and mouth disease were analyzed. Results A total of 9 280 cases were reported under the jurisdiction of the municipality of Nanning six urban areas from 2008 to 2011.Xingning and Xixiangtang district had more incidence,accounted for 77.84%,the peak incidence was obseved from March to July,,sex ratio was 1.65∶1,major violations from scattered children and preschool children,was 97.37%,pathogen detection showed EV71,CoxA16 incidence,age was ranged from 6 months to 3 years,accounted for 84.67%,the incidence rate was quite low under 6 months,accounting for only 2.22%;treatment rate within 3 days after onset was high (95.13%),mild patient with outpatient treatment accounted for 84.94%,accounting for 15.06% of inpatient treatment. Conclusions Hand-foot-mouth' disease is mainly composed of EV71 or CoxA16 in Nanning city of 2008-2011.Summer peak,scattered children and kindergarten children,male were more incidence of primary group,infant under 6 months may have protective antibodies,most mild cases of outpatient service cures.