Objective To observe the relationship of intrauterine infection interleukin-6 (IL-6),and white matter damage (WMD) in preterm infants. Methods 168 preterm children were enrolled in this study from Jan.2010 to May 2012,and divided into WMD group and control group.Intrauterine infection was determined by membranes,placental pathologic examination,WMD was determined by brain ultrasound,and cord serum IL-6 levels were detected by enzyme-linked immunosorbent. Results The incidence of intrauterine infection was 32.1% ( 54/168 ).29 cases were diagnosed WMD,and the incidence of WMD with intrauterine infection premature infants was higher than that of without intrauterine infection preterm infants[35.2%(19/54) vs.8.8%(10/114),χ2=17.899,P<0.001].Compared with control group,gestational age,sex,birth weight and Apgar score in WMD group showed no statistical differences (P>0.05).The umbilical cord blood level of IL-6 in WMD group was significantly higher than that in control group (P<0.001);and its level in preterm infants with intrauterine infection was significantly higher than that in preterm infants without intrauterine infection(P<0.001). Conclusion Intrauterine infection significantly increased the risk of WMD in preterm infants,and cytokines may mediate the process of brain injury in preterm infants with intrauterine infection.
Key words
intrauterine infection /
brain injury /
premature infant /
interleukin-6
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