Objective To observe the behavioral characteristics of attentional flexibility,impulse,spontaneous locomotor activity,cognitive ability in the Spontaneously Hypertensive Rat (SHR),model of attention-deficit hyperactivity disorder (ADHD). Methods To characterize behavioural alterations,attentional set-shifting test,open-field environment test and morris water maze were used in eight juvenile SHR,Wistar-Kyoto(WKY)and SD rats.Prior to training on the set-shifting task,weights were obtained and rats were then food deprived to 85% of the free-feeding standard weight. Results In ASST,the SHR was found decreased mean latency,more trials to reach criterion and more perseverative and regressive errors than the control strains (P<0.01).In open field,the activity levels were significantly higher in SHR than in WKY controls (P<0.01),but there was no significant difference between the SHR and SD rat.During the navigation test,there was no significant difference of latency in SHR(14.41±3.68) and SD rat(16.62±4.65)(P>0.05),WKY rat (23.45±12.02)showed the characteristic of floating.In probe test,SHR (39.92±4.68)showed shorter times stayed in old platform than WKY(54.57±9.34) and SD rat(55.92±8.78)(P<0.01). Conclusions It is important to added SD rats as an additional control to show the behavioral characteristics of SHR in impulse,attentional flexibility,spontaneous locomotor activity and cognitive ability.The SHR is the suitable model used for the study of the behavioral characteristic in the ADHD.
Key words
SHR /
open-field environment test /
morris water maze /
attentional set-shifting
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