Objective To observed the effect of comprehensive intervention measures and routine the 4∶2∶1 care guidance malnourished children in the intervention. Methods 99 malnourished children whose parents were well informed the principle of voluntary participation points for the interventions of the object,were selected and divided into intervention group A,intervention group B,and comprehensive group.Intervention effect evaluation of interventions was finished after one year,with the methods of intervention measures,intervention measures combining traditional chinese and western medicine,and single measures(the conventional 4∶2∶1 care guidance). Results The improved rate of group A was 62.5%,group B was 71.9%,and the control group was 37.1%.Nutritional status improvements of children in both intervention group A and group B were obviously higher than that in comprehensive group,and group B got the fastest improvement(χ²=17.00,P=0.03).After the intervention of Identification & Management of Feeding Difficulty(IMFeD),Group A,group B appetite respectively decreased by 25% and 47%,picky eaters partial eclipse decreased by 50% and 53%,a decrease of bad eating habits by 46.9% and 56.2%. Conclusion The intervention combined with health talks,dietary analysis,reasonable eating behavior intervention and Chinese medicine treatment can effectively reduce the prevalence of malnutrition and it is an effective means to improve the nutritional status of children.