The prevalence of soybean allergy in IgE-associated cow's milk allergic children in Shanghai.
- MIAO Qiong,WANG Xiao-chuan,WANG Jing-yi,YU Ye-heng,WANG Ying.
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Abstract
Objective To determine the prevalence of soybean allergy in IgE-associated cow's milk allergic children in Shanghai. Methods All 441 patients consulting the Children's Hospital of Fudan University in 2009 were included in this study.The experimental group consisted of 224 patients with personal history suggestive of food allergy with specific IgE to cow's milk protein and the control group consisted of 217 patients with non allergic disease.The patients in control group didn't have history of cow milk allergy and their specific IgE to cow's milk protein was negative.Serum-specific IgE to soya protein were measured in all patients and differences of IgE level between soybean and milk,differences of Soybean allergy in different age and gender groups were analyzed separately.The allergy rate of soybean between the experimental group and the control group was also analyzed to explore the cross allergy phenomenon between milk and soybean. Results In IgE-associated CMA cohort,33 patients(14.7%) had soybean allergy.There was no correlation of specific IgE levels between soybean and cow's milk.And the prevalence of soybean allergy decreased with age.In the control group,13 patients(6%) had soybean allergy and similarly the allergy rate of soybean also decreased with age in this group.There was no cross allergic phenomenon between the milk and soybean after age one. Conclusions In Shanghai,very few young children of IgE-associated CMA(especially of age >1 year) had soybean allergy.Therefore,soybean formula may be alternative for the majority of children with IgE-associated CMA.However,milk and soybean still had certain cross allergy in babies of less than 1 year old,therefore close monitoring for cross allergy reaction is necessary in this age group.
Key words
allergy / soybean / milk allergy / child
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References
[1] Rozenfeld P,Docena GH,Aón MC,et al.Detection and identification of a soy protein component that cross-reacts with caseins from cow's milk[J].Clin Exp Immunol,2002,130(1):49-58.
[2] Klemola T,Vanto T,Juntunen-Backman K,et al.Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy:a prospective,randomized study with a follow-up to the age of 2 years[J].J Pediatr,2002,140(2):219-224.
[3] Szaflarska-Szczepanik A,Gasiorowska J.Prevalence of soya allergy in children with cow's milk allergy[J].Med Wieku Rozwoj,2003,7(2):241-248.
[4] Ahn KM,Han YS,Nam SY,et al.Prevalence of soy protein hypersensitivity in cow's milk protein-sensitive children in Korea[J].J Korean Med Sci,2003,18(4):473-477.
[5] American Academy of Pediatrics.Committee on Nutrition.Hypoallergenic infant formulas[J].Pediatrics,2000,106(2 Pt 1):346-349.
[6] ESPGHAN Committee on Nutrition,Agostoni C,Axelsson I,et al.Soy protein infant formulae and follow-on formulae:a commentary by the ESPGHAN Committee on Nutrition[J].J Pediatr Gastroenterol Nutr,2006,42(4):352-361.
[7] Kemp AS,Hill DJ,Allen KJ,et al.Guidelines for the use of infant formulas to treat cows milk protein allergy:an Australian consensus panel opinion[J].Med J Aust,2008,188(2):109-112.
[8] Arshad SH,Tariq SM,Mathews S,et al.Sensitization to common allergens and its association with allergic disorders at age 4 years:a whole population birth cohort study[J].Pediatrics,2001,108(2):e33.
[9] Bruno G,Giampietro PG,Del Guercio MJ,et al.Soy allergy is not common in atopic children:a multicenter study[J].Pediatr Allergy Immunol,1997,8(4):190-193.
[10] Cordle CT.Soy protein allergy:incidence and relative severity[J].J Nutr,2004,134(5S):1213-1219.
[11] Foucard T,Malmheden Y,Man I.A study on severe food reactions in Sweden-is soy protein an underestimated cause of food anaphylaxis?[J].Allergy,1999,54(3):261-265.
[12] Li J,Dykman RA,Jing H,et al.Cortical responses to speech sounds in 3- and 6-month-old infants fed breast milk,milk formula,or soy formula[J].Dev Neuropsychol,2010,35(6):762-784.
[13] Gilchrist JM,Moore MB,Andres A,et al.Ultrasonographic patterns of reproductive organs in infants fed soy formula:comparisons to infants fed breast milk and milk formula[J].J Pediatr,2010,156(2):215-220.
[2] Klemola T,Vanto T,Juntunen-Backman K,et al.Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy:a prospective,randomized study with a follow-up to the age of 2 years[J].J Pediatr,2002,140(2):219-224.
[3] Szaflarska-Szczepanik A,Gasiorowska J.Prevalence of soya allergy in children with cow's milk allergy[J].Med Wieku Rozwoj,2003,7(2):241-248.
[4] Ahn KM,Han YS,Nam SY,et al.Prevalence of soy protein hypersensitivity in cow's milk protein-sensitive children in Korea[J].J Korean Med Sci,2003,18(4):473-477.
[5] American Academy of Pediatrics.Committee on Nutrition.Hypoallergenic infant formulas[J].Pediatrics,2000,106(2 Pt 1):346-349.
[6] ESPGHAN Committee on Nutrition,Agostoni C,Axelsson I,et al.Soy protein infant formulae and follow-on formulae:a commentary by the ESPGHAN Committee on Nutrition[J].J Pediatr Gastroenterol Nutr,2006,42(4):352-361.
[7] Kemp AS,Hill DJ,Allen KJ,et al.Guidelines for the use of infant formulas to treat cows milk protein allergy:an Australian consensus panel opinion[J].Med J Aust,2008,188(2):109-112.
[8] Arshad SH,Tariq SM,Mathews S,et al.Sensitization to common allergens and its association with allergic disorders at age 4 years:a whole population birth cohort study[J].Pediatrics,2001,108(2):e33.
[9] Bruno G,Giampietro PG,Del Guercio MJ,et al.Soy allergy is not common in atopic children:a multicenter study[J].Pediatr Allergy Immunol,1997,8(4):190-193.
[10] Cordle CT.Soy protein allergy:incidence and relative severity[J].J Nutr,2004,134(5S):1213-1219.
[11] Foucard T,Malmheden Y,Man I.A study on severe food reactions in Sweden-is soy protein an underestimated cause of food anaphylaxis?[J].Allergy,1999,54(3):261-265.
[12] Li J,Dykman RA,Jing H,et al.Cortical responses to speech sounds in 3- and 6-month-old infants fed breast milk,milk formula,or soy formula[J].Dev Neuropsychol,2010,35(6):762-784.
[13] Gilchrist JM,Moore MB,Andres A,et al.Ultrasonographic patterns of reproductive organs in infants fed soy formula:comparisons to infants fed breast milk and milk formula[J].J Pediatr,2010,156(2):215-220.
