Research on the relationship between the serum leptin and Body Mass Index for Children.
- XIE Ying1,LUO Bin1,DU Li-mei2,LI Zeng-ning1.
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Abstract
Objective To explore the relationship between the serum leptin (LP) and development degree for obese children. Methods Height was measured with horizontal height analyzer.Serum LP was measured by ELISA,and t-test,Kruskal-Wallis H test,the rank conversion SNK test,the Spearman's rank correlation were used to analyze the data. Results 238 healthy children were inspected (male 121 cases,117 cases),152 cases in the normal group,61 cases in overweight group,25 cases in the obesity group;There had significant statistical difference in LP among the three groups(P<0.05);There had a positive correlation between serum LP and BMI(rs=0.718,P<0.05);There had significant statistical differences in BMI among the three groups(P<0.05);There had no significant statistical difference in BMI between male and female in three groups(P>0.05). Conclusions With BMI increasing,serum LP is rising,a positive correlation between them indicates that obesity children may exist LP resistance.
Key words
leptin / body mass index / obesity / children
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References
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[3] Cheng-ye JI.Report on childhood obesity in China(1) body mass index reference for screening overweight and obesity in Chinese school-age children[J].Biomedical and Environmental Sciences,2005,18:390-400.
[4] Praveen PA,Roy A,Prabhakaran D.Cardiovascular disease risk factors:a childhood perspective[J].Indian J Pediatr,2012,27(3):115-123. [5] 郎琼,刘长运,陈雪.瘦素抵抗与载脂蛋白E基因多态性对儿童血脂的影响[J].Chin J Obsyet Gynecol Pediatr,2011,7(2):8-11.
[6] 李辉,宗心南,季成叶,等.中国2~18岁儿童青少年超重和肥胖筛查体重指数界值点的研究[J].中华流行病学杂志,2010,31(6):616-620.
[7] 李辉,张璿.中国九市城郊0~7岁儿童的体块指数[J].中国儿童保健杂志,2004,12(1):8-11.
[8] 李瑞珍,夏治,林汉华,等.瘦素/脂联素值与肥胖儿童体质量指数及糖脂代谢的关系[J].实用儿科临床杂志,2007,22(20):1546-1547.
[9] 李宏睿,孙文夏,潘杰.瘦素功能研究进展[J].中国动脉硬化杂志,2004,12(1):108-112.
[10] Bogen DL,Hanusa BH,Whitaker RC.The effect of breast-feeding with and without formula use on the risk of obesity at 4 years of age[J].Obes Res,2004,12:1527-1535.
[11] Von KR,Koletzlo B,Sauerwal T,et al.Breast feeding and obesity:cross sectional study[J].BMJ,1999,319:147-150.
[12] 郑东旖,齐可民,刘兆秋,等.肥胖儿童血浆瘦素水平与早期喂养方式关系的研究[J].中国儿童保健杂志,2006,14(6):564-566.
