Objective To investigate the quality of life and related factors in parents of children with autism. Methods 90 parents of autistic children and 120 parents of normal children were participated.SF-36 was employed to evaluate both groups by questionnaire.Parents of autistic children also completed Clancy Autism Behavior Scale (CABS),Autistic Behavior Checklist (ABC),the Children Autistic Rating Scale (CARS)and Autistic children checked with the Gesell development diagnosis scale. Results 1)Parents of autistic children reported substantially lower scores of SF-36 than that of parents with normal group(P＜0.01).2)The quality of life of parents in low functioning intelligence group was worse than high functioning intelligence group(P＜0.01).3) The quality of life of parents was positively correlated with intelligence of autistic children,and negative correlated with symptom of autistic children. Conclusions Children with autistic disorder took grievous influence on parent's quality of life.Compared with high functioning intelligence group,the low functioning intelligence children's parents had even worse quality of life.