Relationship between intellectual development and changes of serum brain-derived neurotrophic factor in children with febrile seizures.
- ZHOU Ju-hua,FANG Su-zhen,ZHOU Xi-zhong,DU Jiang,ZHAO Qian,LI Hong.
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Abstract
Objective To investigate the pathophysiological effects of serum brain-derived neurotrophic factor (BDNF) level and analyse the relationship with the electroencephalogram (EEG) and mental development in the process of febrile seizures (FS). Methods All cases were divided into three groups.Experimental group was the children with FS(n=73);Control group was the children with acute upper respiratory infection(n=51) and healthy children(n=43).The serum BDNF levels of all groups were detected by ELISA;The brain activity was examined by EEG;The mental development index(DQ) was assessed by development scale. Results The serum BDNF levels in experimental group were greatly higher than those of the control groups(P<0.01).The serum BDNF levels were significantly increased in children with abnormal EEG(P＜0.01 or ＜0.05),especially the children with seizure abnormal EEG.There was no significant correlation between DQ and the serum BDNF(P=0.144). Conclusions The serum BDNF levels in experimental group is significantly increased and might be involved in the development process of FS.BDNF is expected to be a sensitive index for evaluating the degrees of brain damage.There was no significant correlation between serum BDNF and DQ.
Key words
febrile seizures / brain-derived neurotrophic factor / EEG / development of mental
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References
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[6] Shin EJ,Jeong JH,Chung YH,et al.Role of oxidative stress in epileptic seizures[J].Neurochem Int,2011,59(2):122-137.
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[13] Reiss JI,Dishman RK,Boyd HE,et al.Chronic activity wheel running reduces the severity of kainic acid-induced seizures in the rat:possible role of galanin[J].Brain Res,2009,1266:54-63.
