Establishment the cut-off value of congenital hypothyroidism on newborn in Guangzhou city.
- JIANG Xiang,JIANG Jian-hui,LI Bei,WU Jia,CHEN Qian-yu,CAO Wei-feng,JIA Xue-fang,LI Hui.
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Abstract
Objective To get the distribution of thyroid stimulating hormone (TSH) and cut-off value in Guangzhou city. Method The results of 209 534 newborns were analysed from September 2011 to August 2012,which was described by percentiles and ROC curve,and determined the reasonable cut-off value combined with the actual screening results. 【Result】 The distribution of newborn screen was deflection,P99 was 9.63 mU/L,the optimal cut-off value was 14 mU/L by ROC curve,the low cut-off value of our lab was 9 mU/L and the high cut-off value was 25 mU/L. Conclusion It is necessary to establish the reasonable cut-off value before carring out the neonatal screening.The determination of low and high cut-off value and establishment of recall-back methods are effective mode for neonatal screening.
Key words
congenital hypothyroidism / thyroid stimulating hormone / cut-off value / newborn screening
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References
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[3] 孙振球.医学统计学[M].北京:人民卫生出版社,2002:9-19.
[4] 王枫,刘淮,杨莉莉,等.新生儿先天性甲低筛查中TSH召回参考值制定方法的比较[J].中国优生与遗传杂志,2005,13(8):78-80.
[5] 朱文斌,郑玉兰,王旌,等.新生儿甲低筛查TSH切值的讨论[J].中国妇幼保健,2009,24(4):503-504.
[6] 张虹,王静,骆峰,等.江苏省宿迁地区新生儿CH筛查TSH切值的建立与评估[J].中国优生与遗传杂志,2012,20(4):89-90.
[7] American Academy of Pediatrics.Newborn screening for congenital hypothyroidism:Recommended guideline[J].Pediatrics,1993,91(6):1203-1209.
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