Objective To study the influential factors about lipids with simple obesity children,and provide clinic accordance with high risk child of prophase lipid screening and prophase interference. Methods 100 cases of simple obesity children and 100 cases of normal children were selected by random sampling to proceed case control study.Both the two groups were had physique measurement,answer the questionnaire about relevant case history,diet condition,life style.At equal pace,total cholesterol(TC),triglyceride(TG),high-density,lipoprotein,cholesterol(HDL),low-density lipoprotein cholesterol(LDL),apolipoprotein A (apoA) and apolipoprotein B (apoB) were determined with the 12h fasting blood.What was more,using DNA sequencing method to detect the apolipoproteinE gene polymorphism of children both group,then,the effection of environment and gene on lipids was analyzed of simple obesity children. Results Compared to control group,experimental group had higher dyslipidemia rate and parent's high blood lipids,family history of cardiovascular disease,high intake of fat and exercise were influential factors of dyslipidemia in environment (P＜0.05); what was more,apoE3 allele of experimental group had higher levels of TG,TC,LDL and lower levels of HDL,apoA,while apoE4 allele had higher levels of TG,apoB and lower levels of HDL,apoA(P＜0.05).In experimental group,compared to apoE3 allele,the child who carry apoE2 allele had lower levels of TC,LDL and apoB(P＞0.05),apoE4 allele had higher levels of TG,apoB and lower HDL(P＜0.01); Conclusion Parent's high blood lipids,family history of cardiovascular disease,parent's obesity,high intake of fat,exercise and apoE gene polymorphism are influential factors with simple obesity children,apoE4 is one of the risk genes of dyslipidemia and correlated with dyslipidemia of obesity children.