Serum 25-Hydroxyvitamin D concentrations in obese children and its clinical significance.

CHEN Hai-yan; CHEN Meng-ying; PENG Lu-ting; WANG Fei; LI Xiao-mei; LI Rong; LI Xiao-nan.

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Chinese Journal of Child Health Care ›› 2013, Vol. 21 ›› Issue (3) : 247-250.

Serum 25-Hydroxyvitamin D concentrations in obese children and its clinical significance.

CHEN Hai-yan,CHEN Meng-ying,PENG Lu-ting,WANG Fei,LI Xiao-mei,LI Rong,LI Xiao-nan.

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Abstract

Objective To compare the serum 25(OH)D concentrations between obesity children and normal weight children,and to investigate the relationships between 25(OH)D and childhood obesity,glucose and lipid metabolism. Methods Obesity was defined according to "Body mass index growth curves for Chinese children and adolescents aged 0~18 years".The serum 25(OH)D concentrations and parathyroid hormone (PTH) were determined by enzyme linked immunosorbent assay (ELISA).Biochemistry index were assayed by automatic chemistry analysis. Results There were 59 obese children (male 45,female 14,BMI 25.14±4.02) with average age (9.58±2.39) years old,and 35 normal weight children (male 23,female 12,BMI 15.56±1.51) aged (8.92±1.56) years old as control recruited in this study.The serum 25(OH)D concentrations [(45.40±11.86)nmol/L] in obese children were lower compared to control group (59.56±16.08)nmol/L(P<0.001).The serum 25(OH)D concentration was inversely related with BMI SDS (P<0.001),waist circumference (P<0.001),waist-to-hip ratio (r=-0.393,P=0.001) and blood triglyceride (P=0.036).Moreover,triglyceride level in obese children with vitamin D deficiency [serum 25(OH)D ≤50 nmol /L] was higher than that in obese children with 25(OH)D > 50 nmol /L. Conclusions The serum 25(OH) D levels in obese children are lower than those in normal weight children;the serum 25(OH) D is negatively correlated with BMI SDS,waist circumference and blood triglyceride,which implying that vitamin D deficiency may be a risk factor of visceral obesity and metabolism syndrome.

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obesity / vitamin D / children

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CHEN Hai-yan,CHEN Meng-ying,PENG Lu-ting,WANG Fei,LI Xiao-mei,LI Rong,LI Xiao-nan.. Serum 25-Hydroxyvitamin D concentrations in obese children and its clinical significance.[J]. Chinese Journal of Child Health Care. 2013, 21(3): 247-250

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