Objective To learn the variation trend and epidemiologic features of birth defects in Dongguan,and the conclusions can be used as the reference basis for formulating intervention program of birth defects. Method Statistical analysis was done to the data of birth defects monitoring of Dongguan during January 2008 to December 2011. Results 1)The incidence of infants with birth defects was 16.41‰.The prenatal diagnosis in birth defects rate was 19.32% over the period of four years.2) The first five main birth defects were congenital heart diseases,polydactyly,cleft lip and palate,congenital clubfoot,and neural tube malformations.3)The birth defect was related to residence origin of the parents,gender and number of neonates,as well as age of the pregnant women and live condition of perinatal.There were statistically significant for their differences(P all＜0.01). Conclusion The incidence of birth defects is higher than the national average in Dongguan.The prenatal diagnosis rate of birth defects is low,diagnosis should be raised for reducing the incidence of birth defects.