Objective To observe the tic and stereotypy in rat models of tic disorder(TD) induced by iminodipropionitrile(IDPN) or (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI),and provide the evidence of selecting rat models fully reflecting the characteristic behavior change. Methods A total of 30 SD rats were randomly divided into 3 groups,IDPN inducement group,DOI inducement group and control group(n=10).The rats in the IDPN inducement group were intraperitoneally injected 150 mg/kg IDPN,and the treatment were given daily for a consecutive 7 d;those in the DOI inducement group were intraperitoneally injected 1 mg/kg DOI,and the treatment were given daily for a consecutive 15 d;those in the control group were intraperitoneally injected saline,and the treatment were given daily for a consecutive 7 d;the dosing volume was 1 mL/100g.The activity scale scores,stereotypy scale scores and classified stereotypy scale scores were observed and recorded at 1~7 d,14 d,28 d after the successful model making. Results The activity scale scores,stereotypy scale scores in the IDPN and DOI inducement groups were higher than those in the control group at 1~4 d,and all classified stereotypy scale scores except grooming and cage licking in the IDPN and DOI inducement groups were higher than those in the control group (P<0.05).The activity scale scores of rat in the IDPN inducement group were higher than those in the control group and DOI group at 5~7 d,14 d,21 d and 28 d; the stereotypy scale scores of rat in the IDPN inducement group were higher than those in the control group and DOI group at 5 d,7 d,14 d,21 d and 28 d(P<0.05).The classified stereotypy scale scores of wood chip eating,circling,head shaking and choreoathetoid movement of rat in the IDPN inducement group were higher than those in the DOI group;the classified stereotypy scale scores of repetitive paw-to-mouth movements and self-gnawing of rat in the DOI inducement group were higher than those in the IDPN group(P<0.05). Conclusions The IDPN models and DOI models can perfectly copy the high excitement,high activity and tic behavior of TD patients.The behavioral changes of TD models induced by IDPN are more obvious and longer persistence than those of the models induced by DOI.
Key words
tic disorders /
animal models /
iminodipropionitrile /
(±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane /
praxiology
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