Vitamin D status of early infants in winter in northern China

WANG Xiao-yan; JIN Chun-hua; WU Jian-xin; SUN Li-juan; LIU Zhuo; LI Yun-feng; WU Guang-chi

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Chinese Journal of Child Health Care ›› 2013, Vol. 21 ›› Issue (11) : 1178-1181.

Vitamin D status of early infants in winter in northern China

WANG Xiao-yan¹,JIN Chun-hua¹,WU Jian-xin²,SUN Li-juan³,LIU Zhuo²,LI Yun-feng²,WU Guang-chi²

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Abstract

Objective To explore vitamin D status of early infants and provide the evidence for the application. Methods 72 subjects were selected from the infants who were born in winter in northern China.All subjects took vitamin D supplement from the 15th day after birth and accepted history and physical examination during the medication monthly.Umbilical cord blood at birth and the blood of infants at 4 months were collected.The levels of serum 25-(OH)D,calcium,phosphorus and alkaline phosphatase were measured. Results The serum 25-(OH)D level was (21.91±5.75)nmol/L of cord blood and vitamin D status was deficiency in 72 (100.0%) cases.The serum 25-(OH)D level was (108.12±45.30) nmol/L of infants and vitamin D status was deficiency in 10(13.9%) cases.The serum 25-(OH)D levels of vitamin D daily supplement of 200U~,400U~ groups were (112.37±37.98)nmol/L and (133.97±34.93) nmol/L.There were 6(23.1%) cases of the serum 25-(OH)D levels ＜75nmol/L in daily intake of vitamin D 200U~ group and 2 cases (7.1%) in 400U~ group.Calcium,phosphorus,alkaline phosphatase levels of neonates and infants were normal. Conclusions Neonatal vitamin D deficiency is prevalent in the region.Intake sufficient vitamin D as soon as possible after birth could significantly improve neonatal and early infant vitamin D deficiency;vitamin D daily supplement of 200 U could significantly increase serum 25-(OH)D levels.In order to achieve adequate vitamin D nutrition for the general population,400U vitamin D is recommended.

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vitamin D / 25-hydroxyvitamin D / cord blood / infants

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WANG Xiao-yan,JIN Chun-hua,WU Jian-xin,SUN Li-juan,LIU Zhuo,LI Yun-feng,WU Guang-chi. Vitamin D status of early infants in winter in northern China[J]. Chinese Journal of Child Health Care. 2013, 21(11): 1178-1181

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