Objective To determine the concentrations of serum lipids and lipoprotein of small for gestational age neonates(SGA). Methods 47 SGA neonates were enrolled in this study,45 term infant of appropriate for gestational age(AGA) selected randomly were used as the control.Vein blood was collected within 12 hours after birth for biochemical analysis,including total cholesterol (TC),high-density lipoproteins cholesterols (HDL-C) low-density lipoproteins cholesterols (LDL-C),triglyceride(TG),LDL-C/HDL-C,apolipoproteins (apo)A1,apoB and apoB/apoA1.Impact of gestational age (preterm and term),degree of intrauterine growth retardation ( birth weight below the 3th percentile(SGA 1) and between the 3th and 10th percentile(SGA 2) of the local sex-specific distribution for gestational age) and gender (male and female) on the values of SGA were compared further. Results TC(2.41±0.61 vs 2.11±0.78,P<0.05)、LDL-C(0.90±0.44 vs 0.71±0.42,P<0.05)and apo-B(0.40±0.22 vs 0.29±0.15,P<0.01)concentrations,and atherogenic indices,including LDL-C/HDL-C(1.31±1.29 vs 0.82±0.46,P<0.05)and apo-B/apo-A1(0.60±0.35 vs 0.40±0.19,P<0.01)ratios,were found to be higher in the SGA compared to the control group.The SGA 1 neonates had significantly lower TC、HDL-C and apoA1 concentrations,as well as higher apo-B/apo-A1 ratio than the SGA 2 group ( P<0.01 or P<0.05).TG value was lower in preterm than in full-term SGA newborns( P<0.05).No gender difference was observed among SGA newborns. Conclusion SGA neonates displayed profiles of less favorable lipid metabolism in the early postnatal period and more severe degree of intrauterine growth retardation may be associated with higher degrees of lipid disorders,SGA has been shown to be a risk factor for developing cardiovascular disease later in life.Lower TG values in preterm SGA newborns maybe related to their fetal maturity.
Key words
lipid profiles /
lipoprotein /
small for gestational age /
neonate
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References
[1] Bassareo PP,Fanos V,Crisafulli A,et al.Cardiovascular phenotype in extremely low birth weight infants:long-term consequences[J].J Matern Fetal Neonatal Med,2011,24(S2):3-5.
[2] Hofman PL,Cutfield WS.Insulin sensitivity in people born pre-term,with low or very low birth weight and small for gestational age[J].J Endocrinol Invest,2006,29(S1):2-8.
[3] 刘桂玲,赵丽娜,楮丽敏,等.妊娠期高血压疾病对新生儿血脂的影响[J].中国综合临床,2011,27(6):649-652.
[4] Howlader MZ,Parveen S,Tamanna S,et al.Oxidative stress and antioxidant status in neonates born to pre-eclamptic mother[J].Trop Pediatr,2009,55(6):363-367.
[5] Wang X,Cui Y,Tong X,et al.Glucose and lipid metabolism in small-for-gestational-age infants at 72 hours of age[J].J Clin Endocrinol Metab,2007,92(2):681-684.
[6] Barker DJ,Martyn CN,Osmond C,et al.Growth in utero and serum cholesterol concentrations in adult life[J].BMJ,1993,307(6918):1524-1527.
[7] Pecks U,Brieger M,Schiessl B,et al.Maternal and fetal cord blood lipids in intrauterine growth restriction[J].J Perinat Med,2012,40(3):287-296.
[8] Kelishadi R,Badiee Z,Adeli K.Cord blood lipid profile and associated factors: baseline data of a birth cohort study[J].Paediatr Perinat Epidemiol,2007,21(6):518-524.
[9] Yonezawa R,Okada T,Kitamura T,et al.Very low-density lipoprotein in the cord blood of preterm neonates[J].Metabolism,2009,58(5):704-707. [10] Pardo IM,Geloneze B,Tambascia MA,et al.Atherogenic lipid profile of Brazilian near-term newborns[J].Braz J Med Biol Res,2005,38(5):755-760.
[11] Donegá S,Oba J,Maranho RC.Concentration of serum lipids and apolipoprotein B in newborns[J].Arq Bras Cardiol,2006,86(6):419-424.
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