Objective To study the effect of the creatine phosphate in the treatment of severe neonatal asphyxia with myocardial damage. Methods A total of 68 cases of neonatal asphyxia newborns with severe myocardial damage were randomly divided into treatment group and the control group,the control group were treated with conventional treatment,and the treatment group were treated by creatine phosphate except conventional therapy.After treatment for 7 d,the myocardial enzymes changes were compared before and after treatment of the two groups of newborns,and to evaluate the therapeutic effect of the two groups of newborns. Results With creatine phosphate treatment,the therapeutic effect of the treatment group (79.41%) was significantly better than the control group (50%),and the treatment group's creatine kinase (CK:121.2±64.3),creatine kinase co-workers enzyme (CK-MB:22.4±11.3),lactate dehydrogenase(LDH:102.2±45.3),hydroxybutyrate dehydrogenase (HBDH:146.2±102.4),aspartate aminotransferase (AST:30.2±10.2) were less than control group. Conclusion In the treatment of severe neonatal asphyxia with myocardial damage,basic conventional treatment and phosphocreatine help improve the therapeutic effect,reduce the level of myocardial enzymes as soon as possible and worthy of clinical application.