Objective By analyzing 1 502 020 cases of perinatal birth defects,to understood the dynamic changes of the birth defects in Jilin Province from 2002 to 2011,and a better job of birth defects prevention and control work should be done.Method According to hospital-based monitory,perinatal infants aged from 28 weeks of gestation to 7 days after birth in Jilin province from 2002 to 2011 were monitored for birth defects. Results A total of 1 502 020 cases of perinatal were monitored,11 892 cases were found defects in children,the incidence of birth defects was 79.17/10⁴.The main type of defect were congenital heart disease,total cleft lip,polydactyly,congenital hydrocephalus,neural tube defects.The incidences of birth defects in rural and urban areas were 70.01/10⁴ and 89.72/10⁴.The incidence of birth defects of the boys and girls were 84.89/10⁴ and 71.04/10⁴.The incidence of birth defects of the pregnant women aged less 20 years and over 35 years were the highest among all pregnant women.The incidence of congenital heart disease was 13.67/10⁴ in 2011,up from 5.61/10⁴ in 2002,and incidence of polydactyly was 11.69/10⁴ in 2011,up from 5.75/10⁴ in 2002,the incidence of neural tube defects had dropped to 3.47/10⁴ in 2011 from 8.40/10⁴ in 2002. Conclusions Neural tube defects and cleft lip incidence showed a decreasing trend,congenital heart disease and multi-finger (toe) the incidence showed an increasing trend from 2002 to 2011 in Jilin.The factors of birth defects and universal access to health education should be studied to reduce the level of incidence of birth defects,prenatal and postnatal care work.Three-level prevention system are effective preventions of birth defects.