Analysis of clinical characteristics and plasma level of mannose-binding lectin in 68 children with febrile convulsion

WANG Chao-qian; HUA Chun-zhen; LUO Qiao-er; WANG Qi-jing; DAI Kai-li; HUANG Xing-xing; YANG Qin-shu

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Chinese Journal of Child Health Care ›› 2012, Vol. 20 ›› Issue (9) : 841-844.

Analysis of clinical characteristics and plasma level of mannose-binding lectin in 68 children with febrile convulsion

WANG Chao-qian¹,HUA Chun-zhen^1,2,LUO Qiao-er³,WANG Qi-jing²,DAI Kai-li¹,HUANG Xing-xing¹,YANG Qin-shu¹

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Abstract

【Objective】 To analyze the clinical characteristics of febrile convulsion (FC) occurred in children and study the mannose-binding lectin (MBL) levels in plasma at both acute and convalescent stages in the case group. 【Methods】 Plasma samples were separated from whole blood which was collected from children with FC at the acute and convalescent stages during August 2010 to July 2011.The MBL concentrations were measured by ELISA method and the SPSS 11.0 software was used in the study. 【Results】 Among all 68 cases,The mean MBL levels were (595±559)ng/mL at acute stage and (585±466)ng/mL in recovery stage,and no significant difference was found between the two groups (Z=0.207,P=0.836).However,there was a significant correlation of the MBL levels between the two stages (r=0.809,P<0.01).29.4% of all individuals had low MBL levels less than 200 ng/mL at convalescent stage.Acute reaction of MBL was observed in 38.2% children with FC.No correlation was found between MBL levels and CRP levels(r =0.15,P=0.22).It was found that 89.7% of the FC children was caused by acute upper respiratory tract infection.The creatine kinase-MB exceeding normal value was found in 54.1% of all individuals. 【Conclusion】 As a whole,convulsion acting as a kind of stress,had no significant effects on the MBL level in vivo.

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febrile convulsion / mannose-binding lectin / plasma concentration / clinical characteristics / children

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WANG Chao-qian,HUA Chun-zhen,LUO Qiao-er,WANG Qi-jing,DAI Kai-li,HUANG Xing-xing,YANG Qin-shu. Analysis of clinical characteristics and plasma level of mannose-binding lectin in 68 children with febrile convulsion[J]. Chinese Journal of Child Health Care. 2012, 20(9): 841-844

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