Effects of treatment on female idiopathic central precious puberty with gonodotrophine-releasing hormone analogue and growth hormone

SUN Xiao-mei; WU Jin; YANG Fan; LI Pin; WANG Xiu-min

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Chinese Journal of Child Health Care ›› 2012, Vol. 20 ›› Issue (8) : 731-734.

Effects of treatment on female idiopathic central precious puberty with gonodotrophine-releasing hormone analogue and growth hormone

SUN Xiao-mei¹,WU Jin¹,YANG Fan¹,LI Pin²,WANG Xiu-min³

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Abstract

【Objective】 To assess the impact of treatment with Gonadotropin-releasing hormone (GnRH) analogs in combination with growth hormone(GH) in girls with idiopathic central precocious puberty (ICPP). 【Methods】 60 girls with ICPP whose growth velocity (GV) was so slowly that it impaired predicted adult height (PAH) were treated with recombinant human GH and GnRHa for 6 months.No patient showed classical GH deficiency.Before and after treatment,height,GV,and pubertal stage were observed,pelvic ultrasonic examination and X-ray bone age(BA) were detected,PAH was evaluated,and LH-releasing hormone (LHRH) stimulation test and GH stimulation test were performed. 【Results】 The secondary sexual development was regressed with interruption of their menses,reduction of the size of uterus,ovaries and breasts.Plasma FSH and LH peaks after the LHRH test were suppressed.The decreased ratio of BA/CA (chronology age) showed the disrupted maturation of BA.PAH increased from (153.4±1.1)cm to (156.0±1.0)cm (P<0.001) after 6 month treatment.The height SDS for BA (HtSDSBA) improved from 1.91±0.33 to 1.44±0.27(P<0.001),while height SDS for CA (HtSDSCA) from 0.31±0.12 to 0.38±0.15. 【Conclusion】 In gilrs with ICPP especially who have a very short PAH,combination of GnRHa and GH effectively inhibits the gonadal axis and delays bone maturation,improve the predicted adult height.

Key words

idiopathic central precocious puberty / gonadotropin-releasing hormone analogs / growth hormone / predicted adult height

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SUN Xiao-mei,WU Jin,YANG Fan,LI Pin,WANG Xiu-min. Effects of treatment on female idiopathic central precious puberty with gonodotrophine-releasing hormone analogue and growth hormone[J]. Chinese Journal of Child Health Care. 2012, 20(8): 731-734

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