【Objective】 To explore the effective clinical treatment of preschool children with mental retardation,and to observe the effect of the treatment combined of conductive education and acupuncture on intellectual development in preschool children with mental retardation. 【Methods】 Sixty preschool children with mental retardation were randomly divided into two groups (n=30 cases in every group).The cases with chromosomal and genetic metabolic diseases and serious complications had been excluded.In control group,the children were assigned to receive family training at home,such as sensory integration,living skills and social adaptation ability training.In treatment group,the children were received family training and a comprehensive rehabilitation treatment of conductive education combined with acupuncture.And the intelligence of all children were determined both at before and three months after intervention. 【Results】 The total efficiency was 96.66% in treatment group and 73.33% in control group.After the intervention,the IQ in treatment group was significantly higher than that in control group(P<0.05).And the IQ difference between before and after intervention was significantly higher than that in control group(P<0.01). 【Conclusion】 Conductive education combined with acupuncture is an effective treatment at intellectual development and elevation in preschool children with mental retardation,which worthy of clinical application.