【Objective】 To study the effects on promoting gastrointestinal peristalsis by curcumin lavage in different time and dose and to find out the optimal time and dose of curcumin. 【Methods】 Male mice were randomly divided into next groups:control group,atropine group and curcumin 1,5,10,15 day groups.Curcumin [200 mg/(kg·d)] was administrated by gastric lavage daily.In different concentration group,the mice were divided into 100,200,300 mg and 400 mg groups.Curcumin was administrated by gastric lavage daily for 10 days.The gastric residiual rate and the motional rate of small intestine were detected using the ink lavage method. 【Results】 In atropine group,the gastric residiual rate was increased and the motional rate of small intestine was decreased obviously.There were no significant improves in curcumin 1 days and 5 days groups.While in curcumin 10 days and 15 days groups,the gastric residiual rate was decreased and the motional rate of small intestine was increased significantly.There was no obvious difference in 10 days and 15 days groups.Curcumin (100~400 mg/kg) decreased gastric residiual rate and increased the motional rate of small intestine significantly.There was no different effects in different concentration of curcumin. 【Conclusion】 Curcumin [200 mg/(kg·d),10 days] can significantly improve the gastrointestinal peristalsis decreased by atropine in mice.