【Objective】 To observe the effect of Simo decoction,the condition of intolerant infants under Clostridium butyricum powder in treatment of neonatal asphyxia during perinatal period after feeding. 【Methods】 68 infants selected as cases and were randomly divided into the control group (n=36) and treatment group (n=32) cases with amniotic fluid meconium pollution in two groups were treated with gastric lavage,after gastric lavage they could not open the milk until fasting for 6 hours.The control group received the treatment of Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines,Live,and the treatment group was treated with the Simo decoction,Clostridium butyricum powder treatment,daily record of vomiting,amount of milk,stool frequency,abdominal distention disappeared days of age,the days of birth weight,such as age of recovery. 【Results】 The experimental group reduced frequency of vomiting ,and vomiting,abdominal distension disappeared ahead of time,up to 50 kCal/(kg·d) days in advance,to restore the birth weight of the days in advance,with statistically significant (P<0.05). 【Conclusion】 The Simo decoction,Clostridium butyricum powder in treatment of neonatal asphyxia during perinatal period after feeding intolerance,can promote gastrointestinal functional maturation,improve feeding tolerance,and it's safe to human beings.