Potential roles of miR-152 in nonalcoholic fatty liver disease by the bioinformatic analysis

FENG Yue-ying; LIN Hu; SHI Chun-mei; JI Chen-bo; GUO Xi-rong; FU Jun-fen

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Chinese Journal of Child Health Care ›› 2012, Vol. 20 ›› Issue (5) : 391-394.

Potential roles of miR-152 in nonalcoholic fatty liver disease by the bioinformatic analysis

FENG Yue-ying¹,LIN Hu¹,SHI Chun-mei²,JI Chen-bo²,GUO Xi-rong²,FU Jun-fen¹

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Abstract

【Objective】 To provide both theoretical and experimental basis for further study of NAFLD via reviewing the previous studies of miR-152 and bioinformatically predicting target genes of miR-152. 【Methods】 All literature of miR-152 was searched in PubMed.The predicted target genes of miRNA-152 were analysed by function enrichment (gene ontology) and signal transduction pathway enrichment (KEGG). 【Results】 miR-152 had been reported in studies of some cancers,preeclampsia and other diseases.The gene ontology analysis showed the predicted target genes of miR-152 were enriched in sensory organ developmentm,cell differentiation,metablism and other biological processes,and the pathway analysis showed the target genes mainly involved in cancers,actin cytoskeleton,adipocytokine,insulin signal and Wnt signaling pathway. 【Conclusions】 There's few study of miR-152 in NAFLD.The predicted target genes of miR-152 are enriched in multiple biological processes,which provid some clues for NAFLD.

Key words

miR-152 / miRNA / bioinformatics / nonalcoholic fatty liver disease

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FENG Yue-ying,LIN Hu,SHI Chun-mei,JI Chen-bo,GUO Xi-rong,FU Jun-fen. Potential roles of miR-152 in nonalcoholic fatty liver disease by the bioinformatic analysis[J]. Chinese Journal of Child Health Care. 2012, 20(5): 391-394

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