【Objective】 To probe the effects of IL-8,IL-10 and NF-kB about qingrejieduliangxuefang combined with montmorillonite powder to infectious diarrheal children. 【Methods】 All 162 outpatients and inpatients suffered with infectious diarrhea were enrolled randomly, but during the study,12 cases were exited because of uninsistence.So 150 cases were given to viral enteritis group and bacterial enteritis group,8 normal children were as normal group and the expression of related factors of pre-treated and post-treated were tested.Children were randomly divided into treated Ⅰgroup,treatedⅡgroup,and control group according to treated programs. Retention enema of qingrejieduliangxuefang was given to treatedⅠgroup,and combined with montmorillonite powder to treatedⅡgroup,montmorillonite powder was given to control group.The changes of related factors of pre-treated and post-treated for 5 days and 15 days were tested. 【Results】 Pre-treated,the IL-8 level was without significant difference(P>0.05) in bacterial enteritis and viral enteritis group.The IL-10 level of bacterial enteritis group was lower than that of viral enteritis group(P＜0.01).Pre-treated,the level of IL-8,IL-10 and NF-kB was without significant difference(P>0.05) in treatedⅠgroup,treatedⅡgroup,and control group.At the end of 5 days and 15 days,compared with oneself pre-treated,the expression of each group reduced signally(P＜0.01)and the level of treated Ⅱgroup was superior to treatedⅠgroup and control group(P＜0.05). 【Conclusions】 IL-10 is helpful to indentify bacterial enteritis and viral enteritis.Qingrejieduliangxuefang combined with montmorillonite powder is good to reduce the expression of related factors and promote a speedy recovery of infectious diarrheal children.