【Objective】 To explore the screening method to neonatal and the incidence inborn eye-diseases. 【Methods】 The neonates accepted eye-disease screen including examination to external eye and reflection to red light,who were born in Jinan maternal and child health care hospital from Jan-01,2010 to Nav-30,2010.The following examination to eyeground after mydriasis were used to the neonates who were abnormal in the above two examination and the high risk infants. And then analysed the result. 【Results】 8 002 neonates accepted eye-disease screen.The rate of eye-diseases in neonate were 13.93%.Of the rate of inborn eye-diseases was 0.67% (54 cases) and the rate of acquired eye-diseases was 13.26% (1 061 cases). 【Conclusion】 There are high incidence of neonatal eye-diseases,so the screening in neonate is much significant to clinical practices.