【Objective】 To observe and compare the curative effect between neonatal touch intervention and low-dose erythromycin treatment on premature infants with feeding difficulties. 【Methods】 90 cases of premature infants with feeding difficulties, which were admitted by the third People's Hospital of Zhengzhou from October 2006 to October 2011,were divided into the experiment group and the control group randomly.Both groups were given with conventional treatments, like warm keeping,postures therapy, partial parenteral nutrition,etc.On the basis of conventional therapy,the experiment group was given extra neonatal touch intervention for 3~5 days,and the control group was given extra low-dose of erythromycin 3~5 mg/kg intravenous infusion for 3~5 days. 【Result】 There was no significant statistically difference (P>0.05) between the experiment group and the control group in course of treatment,vomiting,gastric residual volume, and daily increased milk sucking. 【Conclusions】 Neonatal touch intervention has equivalent curative effect as low-dose erythromycin treatment for premature infants with feeding difficulties.The neonatal touch intervention can be promoted in clinical care to premature infants with feeding difficulties,which can reduce the unnecessary harm to premature infants from drug usage.