【Objective】 To study the characteristic changes of multifocal VEP in strabismic and anisometropic amblyopes,and evaluate the mechanism of amblyopia. 【Methods】 The multifocal pattern VEP of both eyes of 30 strabismic amblyopes,31 anisometropic amblyopes and 30 normal subjects were recorded by VERIS ScienceTM4.2 multifocal visual evoked response imaging system made of America EDI company.The latencies and amplitudes of P waves were analysed.Changes were investigated by comparing the amblyopic eyes,the fellow eyes of the patients and the normal eyes. 【Results】 At six eccentricities the amplitudes of P waves of the amblyopic eyes were reduced and the latencies of P waves were markedly prolonged compared with the fellow eyes and the normal eyes.The mean amplitude of mVEP in the nasal retinal hemifields was smaller than in the temporal retinal hemifields in strabismic amblyopes. 【Conclusion】 Different types of amblyopia may have different neural mechanisms,the results suggest that multifocal VEP could be used in instructing the diagnosis and treatment of amblyopia.
Key words
strabismus /
anisometropia /
amblyopia /
multifocal VEP
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References
[1] Sutter EE,Tran D.The field topography of ERG components in man Ⅰ:The photopic luminance response[J].Vision Res,1992,32:433-436.
[2] Klistorner AI,Grabam SL,Grigg JR,et al.Multifocal topographic visual evoked potential improving objective detection of local visual field defects[J].IOVS,1998,39:937-950.
[3] Demanins R,Wang YZ,Hess RF.The neural deficit in strabismic amblyopia:sampling considerations[J].Vision Res,1999,39(21):3575-3585.
[4] Hess RF,Wang YZ,Demanins R,et al.A deficit in strabismic amblyopia for global shape detection[J].Vision Res,1999,39(5):901-914.
[5] Sireteanu R.The binocular visual system in amblyopia[J].Strabismus,2000,8(1):39-51.
[6] Mckellal M,Polomeno RC,Lepore P,et al.Can interocular pattern reversal visual evoked potential and motor reaction time difference distinguish anisometropic from strabismic amblyopia？[J].Acta Ophthalmol Scand,1999,77(1):40-44.
[7] Kiorpes L,Tang C,Movshon JA.Factors limiting contrst sensitivity in experimentally amblyopic macaque monkeys[J].Vision Res,1999,39(25):4152-4160.
[8] 赵堪兴,刘家琦,郭静秋,等.功能性弱视儿童全视野刺激多导视觉诱发电位地形图研究[J].中华眼科杂志,1990,26(1):68-72.
[9] Lee KM,Lee SH,Kim NY,et al.Binocularity and spatial frequency dependence of calcarine activation in two types of amblyopia[J].Neurosci Res,2001,40(1):147-153.
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