【Objective】 To explore dependablity between the levels of serum gastrin and feeding quantity in premature infants. 【Methods】 42 cases of the premature infants were divided into the two groups:the observe group,which 22 cases of neonatus with feeding intolerance,and the controled group,which 20 cases of neonatus without feeding intolerance.Two groups were detected serum gastrin in 24 h and after 7 days respectively and were observed in clinical condition improved treatment after a week. 【Results】 The levels of the serum GAS and the amount of feeding(Per kilogram of body weight)in premature infants with feeding intolerance were significently lower in 24 h than those in the control group(P<0.05),then they were not significantly different between the two groups after 7 days(P>0.05).The time to establish complete enteral nutrition,days to regain birth weight were significently longer in the observe group than those in the control group,however,the horizontal peak value of total bilirubin of serum and the levels of serum prealbumin were no significant difference between the two groups.None of the two groups have the severe complications such as the necrotized enterocolitis and the inhaled pneumonia.In group 2,there was a positive correlation between the levels of the serum GAS and the amount of feeding(Per kilogram of body weight)(r=0.589,P<0.01). 【Conclusions】 The levels of serum GAS is in close relation with emergence of the function disorder of gastrointestinal tract.The Minimal feeding can promote gastrointestinal developing ripeness.