【Objective】 To explore the effects of lead exposure of pregnant rat on emotion,behavior,learning and memory in filial rats. 【Methods】 Female pregnant Spraque-Dawley (SD) rats were divided into low dose lead exposure group(LG) and high dose lead exposure group(HG) by drinking 0.1% or 0.2% lead acetate dissolved by three distilled water,the normal control group(NG) pregnant rats drank three distilled water.With open field test (OFT),passive avoidance test (PAT) and Morris water maze (MWM) test,the varieties of emotion,behavior,learning and memory were observed in 9~12 male filial rats from HG,LG or NG group. 【Results】 In OFT,the scores of running across squares decreased(36.48±7.24)(F=11.65,P<0.01),the times of standing up by hind legs declined(10.61±3.54)(F=9.49,P<0.01) and the number of dung increased(19.42±3.46)(F=7.27,P<0.01) in filial rats with lead exposure of mother pregnant rats.The results implied that lead exposure of pregnant rat can impair the emotion and behavior in their filial rats.In PAT,increasing times of mistakes (10.38±1.89)(F=8.69,P<0.01) and shortening memory latency [(176.41±41.89)s](F=6.48,P<0.01) were found in lead exposure filial rats.The data suggested that lead exposure of pregnant rat can impair the immediate learning and memory in their filial rats.In Morris water maze test,the prolonged escape latencies of searching the platform(F=4.61,P<0.05),the poor searching strategy (χ2=41.89,P<0.01),the short duration of searching in the platform area (F=6.32,P<0.01) and low frequency swimming above the platform (F=7.13,P<0.01) were found in lead exposure filial rats.The data showed lead exposure of pregnant rat can impair the spatial learning and memory in their filial rats. 【Conclusion】 Lead exposure of pregnant rat can impair emotion,behavior,learning and memory in filial rats.
Key words
lead exposure /
emotion /
behavior /
learning and memory /
rat
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