【Objective】 To observe the changes of serum 25-(OH)D3 in newborns in different gestation ages,to know nutritional status of the vitamin D,and study exogenous vitamin D supplements. 【Methods】 Ninety-five newborns were studied.All the newborns were divided into three groups according to gestational age:Group A had 30 newborns(GA≤33 weeks),Group B had 34 newborns(33 weeks<GA<37 weeks),Group C had 31 newborns(37 weeks≤GA<42 weeks).Serum 25-(OH)D3 was measured within 1 d,14 d,30 d after birth. 【Results】 The mean serum 25-(OH)D3 concentration[(35.03±9.72) nmol/ L] of A group were lower than the mean serum 25-(OH)D3 concentration of B and C group[(41.31±11.35) nmol/L,(42.05±15.93) nmol/L] (P<0.05)1 d after birth.76.8%,53.7% and 75.8% of newborns had vitamin D deficiency (serum 25-(OH)D3 levels ＜50 nmol/L)in 1 d,14 d and 30 d after birth. 【Conclusion】 The vitamin D deficiency of newborns is common,and the vitamin D should be supplied as early as after birth.
Key words
newborn /
25-(OH)D3 /
vitamin D deficiency
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 陈兆聪.维生素D再认识[J].医药导报.2011,30(5):555-560.
[2] Holick MF.Vitamin D deficiency[J].N Engl J Med,2007,357:266-281.
[3] Baqui AH,Arifeen SE,Darmstadt GL,et al.Differentials in neonatal mortality in two adjacent rural areas of Bangladesh: lessons for neonatal health interventions[J].Global Public Health,2008,3:366-382.
[4] Holick MF,Chen TC.Vitamin D deficiency:A worldwide problem with health consequences[J].Am J Clin Nutr,2008,87(4):1080-1086.
[5] Bischoff-Ferrari HA,Giovannucci E,Willett WC,et al.Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes[J].Am J Clin Nutr,2006,84:18-28.
[6] Holick MF.Resurrection of vitamin D deficiency and rickets[J].J Clin Invest,2006,116:2062-2072.
[7] Wagner CL,Greet FR.Prevention of rickets and vitamin D deficiency in infants,children,and adolescents[J].Pediatrics,2008,122(5):1142-1152.
[8] Bondarlm,Simhan HN,Powers RW.High prevalence of vitamin D in sufficiency in black and white pregnant women residing in the northern united states and their neonates[J].J Nutr,2007,137(2):447-452.
[9] 周建烈,魏珉.新生儿维生素D营养健康新概念[J].中国新生儿科杂志,2009,24(3):140-142.
PDF(304 KB)
