【Objective】 To analyze the distribution and drug resistance of bacterial diarrhea of children in Xiamen,and to provide the reference for rational use of drugs. 【Methods】 1 951 cases from August 2007 to December 2011 for clinical diagnosis of infectious diarrhea,took shit vaccination SS and MaiKangKai culture medium for the bacteria cultures.Bacteria identified with France's merry ATB Expression system,and the diagnosis was confirmed with parting serum aggregation.The antimicrobial susceptibility was tested by Kirby-Bauer. 【Results】 92 cases of pathogens were screened out of 1 951 cases of stool specimens,positive rate was 4.72%.Among which 62 plants salmonella spp(67.39%),escherichia coli (pathogenic,aggressive) 21 strains(22.83%),shigella spp 9 strains(9.78%).The resistance to β-lactam antimicrobial was relatively serious in cause diarrhea escherichia coli.Salmonella and shigella were highly sensitive to three generation of cephalosporins and β-lactam add enzyme inhibitors.No resistance found to piperacillin/tazobactam or imipenem. 【Conclusions】 This district children infective diarrhea separation with salmonella bacteria is given priority to,especially in rat typhoid salmonella bacteria are in the majority.The first generation,the second generation cephalosporin should not report sensitive.The resistance to β-lactam antimicrobial is relatively serious in cause diarrhea escherichia coli.Clinical should choose antimicrobial agents for treatment according to antimicrobial susceptibility test results.