【Objective】 To study the pathogenic characterization of the hand-foot-mouth diseases (HFMD) in Cixi in 2011,and to understood the HFMD epidemic trend. 【Method】 Sentinel hospital surveillance for clinical diagnosis of HFMD case specimens were collected.Real-time fluorescence(Real-time) RT-PCR assay was used to detect human enteric viruses (HEV),enterovirus 71 (EV71)and Coxsackie virus group A type 16 (CVA16) of specific nucleic acid. 【Results】 Positive rate of total intestinal virus specimen was 89.97% in 289 cases; Enterovirus 71 and Coxsackie A16 were 58.46% and 22.31% respectively,other type accounted for 19.23%.High positive rate was found in 1~5 years old and male children patients;EV71 positive rate of hospitalized cases was 68.97%. 【Conclusion】 EV71 and CVA16 are the major pathogens of HFMD in Cixi,EV71 infection is much likely to cause severe cases and inpatients,in some area CVA16 is the dominant species.