Effect of hyperbaric oxygen on learning and memory functions in VPA autism rat model

LI Yin; YI Ming-ji; MA Yao

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Chinese Journal of Child Health Care ›› 2012, Vol. 20 ›› Issue (10) : 903-906.

Effect of hyperbaric oxygen on learning and memory functions in VPA autism rat model

LI Yin,YI Ming-ji,MA Yao

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Abstract

【Objective】 To explore the effect of hyperbaric oxygen on learning and memory functions in VPA autism rat model. 【Method】 Animal model of autism was obtained in offspring of the Wistar rats that received a single intraperitoneal injection of sodium valproate at the 12.5 day after pregnancy,the learning and memory of the autism model rats were evaluated by the Y electricity maze test before and after the hyperbaric oxygen intervention. 【Results】 The trying times of the hyperbaric oxygen group were fewer after treatment (31.54±0.88 vs 30.69±0.63,t=5.500,P=0.001) and the memory times were increased(2.85±0.69 vs 3.38±0.65,t=2.214,P=0.047);The trying times of the normobaric hyperoxia group were fewer after treatment(31.54±0.97 vs 31.15±0.99,t=2.739,P=0.018) and the memory times were increased(2.69±0.48 vs 3.00±0.58,t=2.309,P=0.040). 【Conclusion】 The VPA autism rats model is established successfully,the learning and memory abilities are improved after the hyperbaric oxygen intervention.

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valproic acid / hyperbaric oxygen / autism / learning / memory

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LI Yin,YI Ming-ji,MA Yao. Effect of hyperbaric oxygen on learning and memory functions in VPA autism rat model[J]. Chinese Journal of Child Health Care. 2012, 20(10): 903-906

References

[1] Fombonne E.Epidemiological surveys of autism and other pervasive developmental disorders:an update[J].J Autism Der Disorder,2003,33(4):365-382.
[2] Christianson AL,Chesler N,Kromberg JG.Fetal valproate syndrome:clinical and neuro-developmental features in two sibling pairs[J].Dev Med Child Neurol,1994,36(4):361-369.
[3] Go HS,Seo JE,Kim KC,et al.Valproic acid inhibits neural progenitor cell death by activation of NF-kB signaling pathway and up-regulation of Bcl-XL[J].J Biomed Sci,2011,18(1):48-61.
[4] Roullet FI,Wollaston L,Decatanzaro D,et al.Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid[J].Neuroscience,2010,170(2):514-522.
[5] Schneider T,Przewlocki R.Behavioral alterations in rats prenatally exposed to valproic acid:animal of autism[J].Neuropsychopharmacology,2005,30(1):80-89.
[6] 王月华,姚君茹,陈明军,等.BDNF免疫反应阳性神经元在大鼠孤独症动物模型大脑顶叶感觉皮层中的表达[J].神经解剖学杂志,2008,24(3):219-225.
[7] 王晓聪,郑娟,蔡建美,等.高压氧预处理对新生大鼠脑缺血损伤的保护作用[J].中华航海医学与高气压医学杂志,2009,16(6):354-356.
[8] 王跃春.Y型电迷宫在大鼠学习记忆功能测试中的合理运用[J].中国行为医学科学,2005,14(1):69-70.
[9] Dalton KM,Nacewicz BM,Johnstone T,et al.Gaze fixation and the neural circuitry of face processing in autism[J].Nat Neurosci,2005,8(4):519-526. [10] Schneider T,Roman A,Basta-Kaim A,et al.Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid[J].Psychoneuroendocrinology,2008,33(6):728-740.
[11] 金长青,余永利,杜亚松,等.99Tcm-ECD脑血流灌注显像评估儿童孤独症脑血流变化[J].中国医学影像技术,2005,21(6):944-946.
[12] 邓红珠,邹小兵,唐春,等.孤独症儿童脑单光子发射型电子计算机断层显像的研究[J].中国行为医学科学,2006,15(10):885-887.
[13] 孙晓勉,岳静,郑崇勋.孤独症儿童多巴胺转运体脑内显像研究[J].生物医学工程学杂志,2008,25(2):327-330.
[14] Fatemi SH,Reutiman TJ,Folsom TD,et al.GABA(A) receptor downregulation in brains of subjects with autism[J].J Autism Dev Disord,2009,39(2):223-230.
[15] Blatt GJ,Fatemi SH.Alterations in GABAergic biomarkers in the autism brain:research findings and clinical implications[J].Anat Rec(Hoboken),2011,294(10):1646-1652.
[16] 王强,王湘渝,张香菊,等.高压氧对创伤性脑水肿脑组织单胺递质变化的影响[J].中国临床康复,2004,8(34):7729-7731.
[17] 高宝兵,龙志敏,贺桂琼,等.常压高氧处理对APP/PS1转基因小鼠空间学习记忆能力的影响[J].中华行为医学与脑科学杂志,2009,18(12):1064-1066.
[18] 刘玉琪.常压高氧疗法在危重病中的应用[J].医学综述,2009,15(16):2458-2460.
[19] 查晓冰,汪昕,郭美奂,等.高压氧对缺氧缺血性脑损伤大鼠神经细胞凋亡及炎性因子的影响[J].中华航海医学与高气压医学杂志,2009,16(6):357-359.