Relationship between dopamine D4 receptor gene polymorphism and working memory in Chinese boys with attention deficit hyperactivity disorder

YANG Bin-rang; CHEN Xiao-wen; ZHANG Min; PENG Gang; ZHANG Lin-lin

PDF(595 KB)

Chinese Journal of Child Health Care ›› 2012, Vol. 20 ›› Issue (1) : 9-12.

Relationship between dopamine D4 receptor gene polymorphism and working memory in Chinese boys with attention deficit hyperactivity disorder

YANG Bin-rang,CHEN Xiao-wen,ZHANG Min,PENG Gang,ZHANG Lin-lin

Author information +

History +

Abstract

【Objective】 To explore the relationship between the 48 bp variable number of tandem repeat (VNTR) polymorphism in the D4 receptor gene (DRD4) exon 3 and working memory in Han Chinese boys with attention deficit hyperactivity disorder. 【Methods】 The polymorphism of 48 bp VNTR in DRD4 were tested in 80 boys with ADHD and working memory function was measured with digits forward,digits backward,Corsi block recall and visual spatial n-back.They were divided into two groups according to the long-repeat alleles (ranging from 4 to 6 repeats) or the short-repeat alleles (2 or 3 repeat) of DRD4. 【Results】 The repeat numbers of the 48 bp VNTR at the DRD4 ranged from 2 to 6 repeats in boys with ADHD,with the most common being the 4-repeat (73.125%) and 2-repeat (20%) alleles.Neither the 7-repeat allele nor longer repeats were found.The total score and the number of the length in digit backward in ADHD boys with the long-repeat alleles were significantly lower than those with the short-repeat alleles. 【Conclusion】 The long-repeat alleles of DRD4 may affect working memory function in Han Chinese boys with ADHD.

Key words

attention deficit hyperactivity disorder / dopamine / gene / polymorphism / working memory

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

YANG Bin-rang,CHEN Xiao-wen,ZHANG Min,PENG Gang,ZHANG Lin-lin. Relationship between dopamine D4 receptor gene polymorphism and working memory in Chinese boys with attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2012, 20(1): 9-12

References

[1] Faraone SV,Perlis RH,Doyle AE,et al.Molecular genetics of attention deficit hyperactivity disorder[J].Biological Psychiatry,2005,57(11):1313-1323.
[2] Willcutt EG,Doyle AE,Nigg JT,et al.Validity of the executive function theory of attention-deficit/ hyperactivity disorder:A meta-analytic review[J].Biol Psychiatry,2005,57(11):1336-1346.
[3] Froehlich TE,Lanphear BP,Dietrich KN,et al.Interactive effects of a DRD4 polymorphism,lead,and sex on executive functions in children[J].Biological Psychiatry,2007,62(3):243-249.
[4] Herrmann MJ,Walter A,Schreppel T,et al.D4 receptor gene variation modulates activation of prefrontal cortex during working memory[J].The European Journal of Neuroscience,2007,26(10):2713-2718.
[5] Loo SK,Rich EC,Ishii J,et al.Cognitive functioning in affected sibling pairs with ADHD:familial clustering and dopamine genes[J].Journal of Child Psychology and Psychiatry,2008,49(9):950-957.
[6] Szobot C,Roman T,Cunha R,et al.Brain perfusion and dopaminergic genes in boys with attention-deficit/hyperactivity disorder[J].American Journal of Medical Genetics Part B Neuropsychiatry Genetics,2005,132(1):53-58.
[7] Boonstra AM,Kooij JJ,Buitelaar JK,et al.An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD[J].American Journal of Medical Genetics Part B Neuropsychiatric Genetics,2008,147(3):397-402.
[8] Kebir O,Tabbane K,Sengupta S,et al.Candidate genes and neuropsychological phenotypes in children with ADHD:review of association studies[J].J Psychiatry Neurosci,2009,34(2):88-101.
[9] 杨斌让,陈小文,张民,等.两种亚型注意缺陷多动障碍男童执行功能特征[J].中国儿童保健杂志,2011,19(12):1084-1087. [10] 钱秋谨,王玉凤,李君,等.注意缺陷多动障碍与多巴胺D4受体和多巴胺载体蛋白基因多态性的关系[J].北京大学学报:医学版,2003,35(4):412-418.
[11] Leung PWL,Lee CC,Hung SF,et al.Dopamine receptor D4 (DRD4) gene in Han Chinese children with attention-deficit/hyperactivity disorder (ADHD):increased prevalence of the 2-repeat allele[J].American Journal of Medical Genetics,Part B,2005,133 (1):54-56.
[12] Chang FM,Kidd JR,Livak KJ,et al.The worldwide distribution of allele frequencies at the human dopamine D4 receptor locus[J].Human Genetics,1996,98:91-101.
[13] Qian Q,Wang Y,Li J,et al.Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population[J].Am J Med Genet B Neuropsychiatr Genet,2007,44 (2):200-206.
[14] Qian Q,Wang Y,Zhou R,et al.Family-based and case-control association studies of DRD4 and DAT1 polymorphisms in Chinese attention deficit hyperactivity disorder patients suggest long repeats contribute to genetic risk for the disorder[J].American Journal of Medical Genetics Part B,2004,128:84-89.
[15] Brookes KJ,Xu X,Chen CK,et al.No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study[J].BMC Medical Genetics,2005,6(31):1-6.
[16] 黄颐,刘协和,李涛,等.多巴胺 D4受体第3外显子48 bp可变重复序列多态性与抽动障碍的传递不平衡检测[J].中华医学遗传学杂志,2002,19(2):100-103.
[17] Cheuk DK,Li SY,Wong V.Exon 3 polymorphisms of dopamine D4 receptor (DRD4) gene and attention deficit hyperactivity disorder in Chinese children[J].American Journal of Medical Genetics Part B,2006,141:907-911.
[18] 赵爱玲,苏林雁,张玉虎,等.多巴胺D4受体基因和5-羟色胺转运体基因与注意缺陷多动障碍及其相关症状的关联分析[J].中华精神科杂志,2005,38(3):161-164.
[19] 赵爱玲,苏林雁,罗学荣,等.多巴胺D4受体基因与注意缺陷多动障碍及其相关症状的关联分析[J].中国行为医学科学,2005,14(3):199-201.
[20] Kebir O,Tabbane K,Sengupta S,et al.Candidate genes and neuropsychological phenotypes in children with ADHD:review of association studies[J].J Psychiatry Neurosci,2009,34(2):88-101.
[21] Wang E,Ding YC,Flodman P,et al.The genetic architecture of selection at the Human dopamine receptor D4 (DRD4) gene locus[J].American Journal of Human Genetics,2004,74:931-944.
[22] 钱秋谨,王玉风,周儒伦,等.多巴胺D4受体基因多态性与注意缺陷多动障碍的关联分析[J].中华精神科杂志,2001,34(3):134-137.