【Objective】 To investigate the changes of plasma somatostatin (SS) and its correlation with cellular immune function in neonates with hypoxic-ischemic encephalopathy(HIE). 【Methods】 Fifty cases of HIE were collected to detect the SS and T lymphocyte subsets,IL-2,sIL-2R as well as IL-6 levels by radioimmunoassay,APAAP and doube antibody sandwith ELISA methods. 【Results】 The SS and sIL-2R levels in patients with HIE were significantly higher (P<0.01),While the proportion of CD4+/CD8+,the percentages of CD3+ and CD4+ T subtype and IL-2 as well as IL-6 levels were significantly lower (P<0.01) than those in control group.The SS levels in patients with HIE had significantly negative corrections with the proportion of CD4+/CD8+,the percentages of CD3+ and CD4+ T subtype,IL-2 and IL-6 levels,and a significantly positive corrlation with levels of sIL-2R(P<0.01). 【Conclusions】 High level of SS is related to HIE,and there is a strong negative correlation between SS and cellular immune function in patients with HIE.
Key words
hypoxis-ischemic encephalopathy /
somatostatin /
immunity /
cellular /
newborn
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