【Objective】 To investigate the potential roles of tumor necrosis factor related apoptosis inducing ligand (TRAIL) and its soluble receptors (sTRAILR1 and sTRAILR4) in the pathogenesis of respiratory tract infections,the concentrations of sTRAIL,sTRAILR1 and sTRAILR4 proteins were determined. 【Methods】 Concentrations of sTRAIL and sTRAILR1 and sTRAILR4 protein were detected by ELISA,in patients with bronchiolitis and acute upper respiratory infection and individuals(named bronchiolitis group,AURI group,control group). 【Results】 The concentrations of sTRAIL,sTRAILR1 and sTRAILR4 protein were significantly higher in bronchiolitis group (85±38),(71±19),(167±97) pg/mL,respectively and in AURI group(78±28),(61±15),(139±72) pg/mL than those in control group(55±19),(45±14),(56±38) pg/mL,respectively(P all<0.01).Data also showed that the concentration of sTRAILR1 protein was markedly higher in bronchiolitis group than that in AURI group(P all<0.05).While no significance were observed of sTRAIL and sTRAILR4 expressions between the patients with bronchiolitis group and in AURI group(P>0.05).Furthermore,levels of sTRAILR1 was highly correlated to sTRAIL and sTRAILR4(n=102,r=0.236 and 0.409 respectively,all P<0.01). 【Conclusion】 Levels of sTRAIL,sTRAILR1 and sTRAILR4 were elevated in bronchiolitis and AURI which could be applied as an effective targets of patient's condition judgment.Our study indicated TRAIL and its receptors may involved in the pathogenesis of bronchiolitis and AURI inflammation.
Key words
enzyme linked immunosorbent assay /
bronchiolitis /
acute upper respiratory infection /
tumor necrosis factor related apoptosis inducing ligand /
receptor
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