【Objective】 To explore the neurobehavioral development condition of infants with mild or moderate neonatal hypoxic-ischemic encephalopathy(HIE) during early period of standard treatments. To provide the theory evidence for evaluation and study of infant neurobehavioral development with HIE. 【Methods】 Mild and moderate HIE infants were assigned into two groups based on GM1 treatment. Normal infants born in the same period at the Heilongjiang Hospital were used as control group. One-year regular visiting study was launched and infants from all three groups were assessed using Gesell table at 3 months, 6 months, and 12 months old. 【Results】 1)At 3 months old, all developmental quotient (DQ) of the five items from group 1 and group 2 were lower than control group (normal infants) and there was very significant difference (P<0.001). 2) At 6 months old, there was no significant difference between group 1 (mild HIE infants) and control group (P>0.05) while significant difference exited between group 2 and control group (P<0.05). 3)At 12 months old, there was still significant difference between group 2 and control group with respect of fine movements and adaptive behavior(P＜0.05). 【Conclusions】 Mild and moderate hypoxic-ischemic encephalopathy may have a more slow neurobehavioral development than normal infants. As they grow up, intelligence and behavior will be gradually improved, such as coarse movement, language level and social communication. Moderate hypoxic-ischemic encephalopathy may have a slow improvement in fine movement and adaptive behavior. In future work, more attentions will be paid on interventions like fine movement and adaptive behavior.