【Objective】 To investigate the changes and clinical significance of body mass index (BMI), serum insulin-like growth factor 1 (IGF-1) and leptin in the female children with idiopathic central precocious puberty (ICPP) and simple premature thelarche (SPT). 【Methods】 BMI, serum IGF-1 and leptin were detected in 28 female children with ICPP and 32 cases with SPT. 26 children with normal puberty and 30 underdeveloped children were as control group. The correlations of BMI, serum IGF-1 and leptin were analyzed. The diagnostic value of IGF-1 and leptin was evaluated in the patient with ICPP. 【Results】 The serum levels of IGF-1 and leptin in the patients with ICPP were higher than those of children with SPT and the underdeveloped children, which there was statistical significance (P<0.01). There was no statistical significance between ICPP and the normal puberty groups (P>0.05). Serum level of IGF-1 and leptin were both positively correlated with BMI (r=0.67,0.71,P<0.01) in the patients with ICPP, and there were also positive correlations between IGF-1, leptin and BMI (r=0.63,0.68,P<0.01) in the children with normal puberty. There were no correlations between IGF-1, leptin and BMI in the children with SPT and underdeveloped children. The sensitivity, specificity and positive predictive value were 95.4%, 96.3% and 95.6% respectively for the diagnosis of ICPP when the serum IGF-1 was above 319.47 ng/mL. The sensitivity, specificity and positive predictive value were 96.5%, 95.7% and 94.8% respectively for the diagnosis of ICPP when the serum leptin was above 6.32 ng/mL. 【Conclusions】 The serum level of IGF-1 and leptin are useful for differential diagnosis of ICPP with SPT and can be as reference factors for the diagnosis of ICPP. IGF-1 and leptin are probably the factors in the activating of the GnRH pulse secretion.
Key words
precocious puberty /
insulin-like growth factor 1 /
leptin /
simple premature thelarche
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