【Objective】 To evaluate the clinical application of non-nutritive sucking touching associated with massage interfere in preterm infants fed with gastric tube. 【Methods】 68 preterm infants appropriate for gestational age and without other complications were evaluated. They were randomly divided into two groups: the intervention group and the conventional fed group. The intervention group infants accepted non-nutritive sucking and massage intervention in the case of conventional fed, all the information of preterm infants were recorded, including the duration of meconium, the last days of physiological weight loss, the retention time of gastric canal, the incidence of feeding intolerance, the incidence of complications, length of stay in hospital and other indicators. 【Results】 There were significant differences between the intervention group and the conventional fed group in the duration of meconium, last days of physiological weight loss, the retention time of gastric canal, length of stay in hospital(P<0.05). The incidence of feeding intolerance and concurrent disease in the intervention group were less than formula-fed group, the differences were also significant(P<0.05). About the complications in two groups of preterm infants, the incidence of hyperbilirubinemia was the highest, the rate of the conventional fed group was 44.1%, the rate of the intervention group was 14.7%, the difference between them was significant(P<0.05). At 40 weeks gestational age corrected, the weight, length and head circumference of the intervention group infants were better than the conventional fed group infants, and the difference between them were significant(P<0.05). 【Conclusion】 Non-nutritive sucking touching joint intervention play good role in promoting feeding in preterm infants.