【Objective】 In order to improve the service and management level of the neonatal screening work, pull the modern information technology into this field. 【Methods】 The "Beijing neonatal screening information management system" were designed which was based on the Hanxin code and on the basis of Beijing maternal and children information network. 【Results】 Neonatal screening information system could screen samples from the new collection, delivery, laboratory tests, to recall suspected cases, diagnosis, treatment, follow-up the whole process of information, which had a good supporting management and public inquiries function. 【Conclusion】 It is necessary and advantageous to build a new screening information management system, which can optimize the new screen business processes, improve the management level.