Study on the relationship between the blood lead level and behavior problems in the preschool children aged 3～7 years old in Shunyi district
- LIU Ya-jing1, JIA Mei-xiang2, HE Ya-ping1, WANG Xiu-yun1, XIANG Zheng1, CUI Wen-hong1, LI Xue-ling1, LIU Jian-hua1, JI Wei-long1
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Abstract
【Objective】 To observe blood lead level and distributed characteristics among children of 3～7 years old in Shunyi district in Beijing and to explore the effects of lead poisoning on preschool children behaviors. 【Methods】 1 307 children of 3～7 years old were investigated from April to June 2009. All subjects were selected from 5 kindergartens through a clustered-random sampling in Shunyi district.Blood lead level was measured and behavior problems were made by CBCL.All children were divided into 2 group(high blood lead group and low blood lead group)by blood lead beyond or below 100 μg/L .The behavior problems were identified while the total crude scores of CBCL beyond 42 in boys and 45 in girls. 【Results】 The geometric mean of blood lead was (3.328±2.765) with 1.22% of those ≥100 μg/L,and 0.15%≥200 μg/L.The median of CBCL total crude scores in high blood lead group was significantly higher than those of low blood lead group(P<0.001).The ratio of behavior problems in high blood lead group(76.47%) was significantly higher than that of low blood lead group(10.85%)(P<0.001).The ratios of behavior of attack, hyperactivity and disobey were significantly higher in high blood lead group than those of low blood lead group in boys(P<0.05). The ratio of behavior of disobey was significantly higher in high blood lead group than that of low blood lead group in girls(P<0.001). 【Conclusions】 Preschool children lead poisoning is associated with their behavior problems. Promoting healthy information can alleviate danger of high blood lead.
Key words
high blood lead / preschool children&apos / s health / behavior problems
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References
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[3] CDC. Laboratory standardization: lead. Atlanta, GA: centers for disease control and prevention[R/OL]. 2006,http:∥www.cdc.gov/nceh/dls/lead.html.
[4] Binns HJ, Campbell C, Brown MJ. Interpreting and managing blood lead levels of less than 10 μg/dL in children and reducing childhood exposure to lead: recommendations of the Centers for Disease Control and Prevention Advisory Committee on childhood lead poisoning prevention[J]. Pediatrics,2007,120(5):e1285-e1298.
[5] Brown MJ. Interpreting and managing blood lead levels <10 μg/dL in children and reducing childhood exposures to lead: recommendations of CDC's Advisory Committee on Childhood Lead Poisoning Prevention [J]. MMWR Recomm Rep,2007,56(RR-8):1-16.
[6] 梁晓红,朱兰芳,刘秋华,等.4～5岁学龄前儿童血铅与行为问题关系的研究[J].中国妇幼保健,2006,21(21):2955-2957.
[7] Bellinger DC. Very low lead exposures and children's neurodevelopment[J].Curr Opin Pediatr,2008,20(2):172-177.
[8] Lanphear BP, Hornung R, Khoury J, et al. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis[J]. Environ Health Perspect,2005,113(7):894-899.
[9] Brubaker CJ, Schmithorst VJ, Haynes EN, et al. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study[J]. Neurotoxicology,2009,30(6):867-875.
[10] 余高妍,颜崇淮,余晓刚,等.慢性中度铅中毒对幼兔海马组织的影响[J].中华预防医学杂志,2008,42(3):160-164.
