Measurement and analysis on markers of bone metabolism in neonates
- WANG Ai-ping1, TAO Na1, LI Yang-fang1, YANG Ru-wen2, LIU Rong-jun2, WU Yu-qin1, SHEN Jin1, ZHANG Yan1
Author information
+
History
+
Abstract
【Objective】 To explore characters of bone metabolism in neonates. 【Methods】 The concentrations of serum osteocalcin (OC), beta-crossLaps (β-CTx), calcium, parathyroid hormone (PTH) and 25-hydroxycholecalciferol [25(OH)D3] were measured in 30 appropriate for gestational age(AGA) term infants, 17 small for gestational age(SGA) term infants, 33 AGA preterm infants and 6 SGA preterm infants, and the data were statistically analyzed. 【Results】 The concentrations of serum OC in group of SGA term infant and AGA preterm infants were less than that in group of AGA term infant(P<0.05); The concentrations of serum β-CTx in group of AGA term infant was less than that in group of AGA preterm infant(P<0.05); The concentrations of serum calcium in group of SGA and AGA preterm infant was less than that in group of AGA term infant(P<0.05); The concentrations of serum PTH in group of AGA preterm infant was less than that in group of AGA and SGA term infant(P<0.05); The concentrations of serum 25(OH)D3 had no statistical difference in group of AGA term infant 、SGA term infant、AGA preterm infant and SGA preterm infant(P>0.05). 【Conclusions】 The SGA term infant, AGA and SGA preterm infant easily occur metabolic bone diseases, the supervisal in metabolic bone diseases for them should be strengthened, and Vitamin D difficiency rickets in AGA term infant should be paid attention to supervise too.
Key words
osteocalcin / serum beta-crossLaps / serum calcium / parathyroid hormone / 25-hydroxycholecalciferol / neonates
{{custom_sec.title}}
{{custom_sec.title}}
References
[1] 张会丰,王卫平.儿童、青少年骨健康:骨纵向生长、骨塑造和骨再造[J].中国儿童保健杂志,2011,19(4):299-300.
[2] Domenech E, Diaz-Gomez NM, Barroso F, et al. Zinc and perinatal growth[J].Early Hum Dev,2001,65(S):111-117.
[3] 徐亚萍,俞惠民.早产儿骨转化及早期静脉补钙对骨转化的影响[J].浙江大学学报:医学版,2003,32(5):418-422.
[4] 林岚, 张春玲, 张小玲, 等.佝偻病患儿骨代谢生化标志物的检测[J].广东医学,2006,27(10):1525-1527.
[5] Cao G, Gu Z, Ren Y, et al. Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium[J]. Endocrinology,2009,150(2):561-569.
[6] Millen AE, Bodnar LM.Vitamin D assessment in population-based studies: a review of the issues[J]. Am J Clin Nutr,2008,87(4S):1102-1105.
[7] 吴康敏.我国儿童骨健康的研究现状与发展[J].中国儿童保健杂志,2011,19(4):297-298.
[8] Akcakus M, Koklu E, Budak N, et al. The relationship between birth weight, 25-hydroxyvitamin D concentrations and bone mineral status in neonates[J]. Ann Trop Pediatr,2006,26(4):267-275.
[9] Van Leeuwen JP, Van Driel M, Van Den Bemd GJ, et al.Vitamin D control of osteoblast function and bone extracellular matrix mineralization[J]. J Crit Rev Eukaryot Gene Expr,2001,11(1-3):199-226.
[10] Miao D, He B, Karaplis AC, et al. Parathyroid hormone is essential for normal fetal bone formation[J]. J Clin Invest,2002,109(9):1173-1182.
[11] Xue Y, Karaplis AC, Hendy GN, et al. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development[J]. Hum Mol Genet,2005,14(11):1515-1528.
[2] Domenech E, Diaz-Gomez NM, Barroso F, et al. Zinc and perinatal growth[J].Early Hum Dev,2001,65(S):111-117.
[3] 徐亚萍,俞惠民.早产儿骨转化及早期静脉补钙对骨转化的影响[J].浙江大学学报:医学版,2003,32(5):418-422.
[4] 林岚, 张春玲, 张小玲, 等.佝偻病患儿骨代谢生化标志物的检测[J].广东医学,2006,27(10):1525-1527.
[5] Cao G, Gu Z, Ren Y, et al. Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium[J]. Endocrinology,2009,150(2):561-569.
[6] Millen AE, Bodnar LM.Vitamin D assessment in population-based studies: a review of the issues[J]. Am J Clin Nutr,2008,87(4S):1102-1105.
[7] 吴康敏.我国儿童骨健康的研究现状与发展[J].中国儿童保健杂志,2011,19(4):297-298.
[8] Akcakus M, Koklu E, Budak N, et al. The relationship between birth weight, 25-hydroxyvitamin D concentrations and bone mineral status in neonates[J]. Ann Trop Pediatr,2006,26(4):267-275.
[9] Van Leeuwen JP, Van Driel M, Van Den Bemd GJ, et al.Vitamin D control of osteoblast function and bone extracellular matrix mineralization[J]. J Crit Rev Eukaryot Gene Expr,2001,11(1-3):199-226.
[10] Miao D, He B, Karaplis AC, et al. Parathyroid hormone is essential for normal fetal bone formation[J]. J Clin Invest,2002,109(9):1173-1182.
[11] Xue Y, Karaplis AC, Hendy GN, et al. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development[J]. Hum Mol Genet,2005,14(11):1515-1528.
