【Objective】 To explore the effects of early intervention on healthy personality development in infants and the evidence for optimized nurture and education. 【Methods】 From October 2007 to October 2010, 21 hospitals in China took part in the research of early integrate intervention on infants of 0~3 years of age. 594 eligible normal newborn infants were randomly assigned to early intervention group(301 cases) and control group(293 cases). Regular follow-up and general parenting guidance were performed for both groups. In addition to the common guidance, individualized instructions and training courses for parents were organized by well-trained professionals. The standard instruments used to assess the effect of intervention were Chattel's Sixteen Personality Factor Scale(16pf), Temperament Questionnaire(1~4 months old and 12~36 months old), Personality Tendency Scale for Children(PTSC), Children Behavior Check list(CBCL), CDCC Scale of infant development(CDCC) and Child Home Nurture Environment Scale. 【Result】 The mean scores of Personality Tendency for Children, CDDD, Children Behavior Checklist and Temperament in the intervention group were significantly better than those for control group(P<0.05 or ＜0.01). 【Conclusion】 Early intervention can significantly promote the formation of a healthy personality of early childhood; it is a golden stage to cultivate infants' healthy personality in 0 ~ 3 years old.