【Objective】 To observe the effect to improve the follow-up rate and effect by regulatory reservation to see a doctor in follow-up center for high risk neonates, offer evidence in order to generalize the system.【Objects】 According to voluntary principle, 2 929 high-risk neonates who took part in reservation to see a doctor voluntarily and established files from division of neonatology from May 2009 to April 2010 were chosen as reservation group, and who established files from division of neonatology at the same term and see a doctor without reservation as usual were chosen as control group. 【Methods】 High-risk neonates of reservation group were planned to make an appointment of follow-up time by many way such as education when discharge from hospital, telephone booking and spot booking by specialist nurse, hospital booking form network platform. High-risk neonates of control group were to see a doctor conventionally without reservation. 【Results】 After 1 year follow-up management, the follow-up rate of the first time of reservation group was significantly increased 26.99％ than that of control group(P<0.001), reached to 82.72%. The follow-up rate of one-year of reservation group was significantly increased 30.82％ than that of control group(P<0.001), reached to 63.4％. The time patients waiting for the medical treatment was significantly shortened from(18.965±20.048) minutes to(6.125±8.048) minutes after reservation. 【Conclusions】 Planning to make an appointment of follow-up time can greatly improve the follow-up rate and effect of high risk neonates and shorten the waiting time in follow-up center.