【Objective】 To observe the clinical characters and treatments of cow's milk protein allergy(CMPA)infants. 【Method】 23 cases were diagnosed as cow's milk protein allergy by CMP elimination in 2009, the clinical data were analyzed retrospectively. 【Results】 The patients consisted of 14 males and 9 females,whose course of disease ranged from 2 weeks to 3 months. The main clinical manifestation were chronic diarrhoea, bloody stool, vomiting or gastroesophageal reflux disease, constipation, food refusal and atopic eczema; Extensively hydrolyzed formula and probiotics improved the symptoms in all 23 cases. 【Conclusions】 The gastrointestinal symptoms caused by cow's milk protein allergy is nonspecific and diagnosis is difficult. Extensively hydrolyzed formula and probiotics can be used to confirm the diagnosis and improve the prognosis.