【Objective】 To analyse the relationship between the kawasaki disease (KD) children's hematology parameters at different times and the coronary artery disease by comparing KD group with control group, so that provide clinical prognosis objective basis. 【Method】 Compared the white blood cell (WBC), hemoglobin (Hb) , platelet (PLT), haematocrit (HCT), C-reactive protein (CRP ) and erythrocyte sedimentation rate (ESR) of clinical definite 48 KD children, which were separated into 2 groups: 18 coronary artery injury and 30 contol on the day or the next, 1 week and two weeks after Admission. 【Results】 Compared the WBC & PTL of oronary artery injury group and control group on the admission day or the next, the difference was significant (P<0.05), but no difference was found between 1 week and 2 weeks after admission (P>0.05). There was no difference between two groups' Hb on the day or the next, 1 week and two weeks after Admission (P>0.05). No difference was found between two groups' HCT on the admission day or the next (P>0.05), however HCT had significant difference between two groups in 1 week and 2 weeks after admission (P<0.001 or 0.05). 【Conclusion】 WBC & PLT can be used as prediction index of KD in children, and the changes of HCT is an import ant index in assessing the risk level of KD children.