【Objective】 To explore the features of plasma NTproCNP and the relationship during NTproCNP, IGF-I and estrogen in girls with idiopathic central precocious puberty. 【Methods】 A total of 16 cases of girls with idiopathic central precocious puberty(ICPP) were set as ICPP group, while the control group involved 16 healthy girls with age matched. Physical detection indices such as height, body weight and bone age were determined. The bone age was measured with TW2 method, through evaluating the ossification center of the left hand and wrist. Plasma NTproCNP and IGF-I were measured by ELISA, while estrogen(E2) was determined by chemoluminescence assay. 【Results】 In both the control group and ICPP group, plasma NTproCNP levels were(18.92±8.62) pmol/mL and 21.74(13.12)pmol/mL, respectively(Z=2.34,P<0.05). The serum IGF-I levels were(522.41±228.33) ng/mL and(867.50±318.15) ng/mL, respectively(t=3.59,P<0.05). The serum estrogen levels were 19.00(4.5) pg/mL and(37.19± 16.08) pg/mL, respectively(Z=2.58,P<0.05). In both ICPP group and control group, plasma NTproCNP level had no correlation with neither age nor bone age; moreover, plasma NTproCNP had no correlation with IGF-I; no correlation was found between NTproCNP, IGF-I and estrogen. 【Conclusion】 The plasma NTproCNP level is significant rising in the girls of ICPP.
Key words
idiopathic central precocious puberty /
estrogen /
longitudinal growth of bone /
C-type natriuretic peptide /
insulin-like growth factor-I
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