【Objective】 To analyze the clinical significance of thrombocytosis in pediatric patients with pneumonia. 【Methods】 209 patients with pneumonia were divided into 2 groups: 102 patients with thrombocytosis (platelet count＞400×109/L, group A), 107 patients with normal platelet counts (group B). Clinical data, laboratory data, plasma tumor necrosis factor-α (TNF-α)and interleukin-6(IL-6) concentrations, tidal breathing lung function were compared. 【Results】 Compared with group B, there were more severe clinical conditions in group A: higher percentage of dyspnea and wheezing and longer hospitalization, higher white blood count, lower lung function parameter including tPTEF、tPTEF/tE、TEF25 and TEF25/PTEF%,higher plasma concentrations of TNF-α and IL-6. The difference between the two groups was statistically significant (P<0.05). There were positive correlation between plasma concentrations of IL-6 and platelet count (r=0.354,P＜0.05). Platelet count was negatively correlated with two kinds of pulmonary function parameters( tPTEF/tE、TEF25)(r= 0.461、0.407,P＜0.05). 【Conclusions】 The severity of pneumonia in children is associated with platelet count. Platelet count is a useful clinical marker in judging the severity of pneumonia and guiding therapy.
Key words
pneumonia /
thrombocytosis /
child
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