【Objective】 To compare the 12 months effect of metformin treatment on obese children. 【Methods】 101 obese children were grouped base on OGTT, Group 1 were 50 with hyperinsulinemia cases, among of them, 20 cases(Group 1A) managed by lifestyle interferering and other 30 cases (Group 1B) treated with metformin. Group 2 were 51 IGR/T2DM cases treated with metformin and lifestyle interfering. 【Results】 Group 1A before and after treatment of the body mass index, index of glucose metabolism, blood lipids,had no significant improvement(P> 0.05). Group 1B and group 2 before and after treatment of the body mass index, index of glucose metabolism, blood lipids,were improved significantly,(P<0.01). 【Conclusion】 Metformin combined with life-style is better than lifestyle alone.
Key words
childhood obesity /
hyperinsulinemia /
abnormal glucose metabolism /
metformin
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