Changes and clinical significance of serum TNF-α, IL-4 and IL-6 in the children with henoch-schonlein purpura
- LIU Wen-dong, YU Ling-xiang, XUE Ai-hong, LI Hong
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Abstract
【Objective】 To explore the changement of serum tumor necrosis factor-alpha-alpha (TNF-α), interleukin-4(IL-4),interleukin-6(IL-6) with allergic purpura and allergic purpura nephritis during the course of the disease. 【Methods】 The serum levels of TNF-α,IL-4,IL-6 were measured with ELISA. 【Results】 At the acute stage, the lever of serum TNF-α, IL-6, IL-4 in HSP group were significantly higher than those in normal control group (P<0.01), in convalescent stage, the lever of serum TNF-α, IL-4, IL -6 were obviously decreased, and the lever of serum TNF-α,IL-4 ,IL-6 were higher in HSPN than in HSP. 【Conclusion】 Cytokine disorder existed in the children with HSP,the TNF-α, IL-4, IL-6 may play important roles in patho-genesis of HSP and HSPN.
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References
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[2] 叶世泰.变态反应学[M].北京:科学出版社, 1998:521-523.
[3] Calvino MC, Llorca J, Garcia-Porrua C, et al. Henoch-Schonlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study[J]. Medicine,2001,80(5):279-290.
[4] Rostoker G. Henoch-Schonlein purpura in children and adults:diagnosis, pathophysiology and management[J].Biol Drugs,2001,15(2):99-138.
[5] Wiercinski R, Zoch-Zwierz W, Wasilewska A, et al. Lymphocyte subpopulations of peripheral blood in children with Schonlein-Henoch purpura and IgA nephropathy[J]. Pol Merkuriusz Lek, 2001,10(58):244-246.
[6] 陈慧,江明华,杨军军,等.过敏性紫癜患儿免疫功能的变化[J].实用医学杂志,2002,18(10):1053-1055.
[7] 林瑞霞,杨青,陈敏广,等.黄芪地黄汤对小儿过敏性紫癜肾炎Th1 /Th2的影响[J].中国中西医结合肾病杂志, 2008, 9(2):134-136.
[8] Cabellos C, Macintyre DE, Forrest M, et al. Differing roles for platelet-activating factor during TNFlammation of the lung and subarachnoid space[J]. J Clin Invest, 1992,90(2):612-618.
[9] Ha TS.The role of tumornecrosis factor-alpha in Henoch-Schonleinpurpura[J]. Pediatr Nephrol,2005,20(2): 149-153.
[10] Shin JI, Kim JH, Lee JS.The diagnostic value of IgA deposition inHe-noch-Sch nlein purpura[J]. Pediatr Dermatol,2008, 25(1): 140-141.
